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Product Details
15339-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2400 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:500 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
POLR3D Fusion Protein Ag7542 (45-398 aa encoded by BC004484) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.4 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: SRDLTLGGV KKKTFTPNII SRKIKEEPKE EVTVKKEKRE RDRDRQREGH GRGRGRPEVI QSHSIFEQGP AEMMKKKGNW DKTVDVSDMG PSHIINIKKE KRETDEETKQ ILRMLEKDDF LDDPGLRNDT RNMPVQLPLA HSGWLFKEEN DEPDVKPWLA GPKEEDMEVD IPAVKVKEEP RDEEEEAKMK APPKAARKTP GLPKDVSVAE LLRELSLTKE EELLFLQLPD TLPGQPPTQD IKPIKTEVQG EDGQVVLIKQ EKDREAKLAE NACTLADLTE GQVGKLLIRK SGRVQLLLGK VTLDVTMGTA CSFLQELVSV GLGDSRTGEM TVLGHVKHKL VCSPDFESLL DHKHR (45-398 aa encoded by B C004484)
Target Information
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BN51 (BHK21) temperature sensitivity complementing; DNA-directed RNA polymerase III 47 kDa polypeptide; DNA-directed RNA polymerase III subunit C4; DNA-directed RNA polymerase III subunit D; DNA-directed RNA polymerase III subunit RPC4; HOX1C; polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; polymerase (RNA) III subunit D; Protein BN51; RNA polymerase III 47 kDa subunit; RNA polymerase III subunit C4; RPC53 homolog; temperature sensitive complementation, cell cycle specific, tsBN51
Gene Aliases: 2810426M17Rik; 44kDa; AI326118; AW489084; BN51; BN51T; POLR3D; RPC4; RPC53; TSBN51
UniProt ID: (Human) P05423, (Mouse) Q91WD1
Entrez Gene ID: (Human) 661, (Mouse) 67065, (Rat) 306012
Molecular Function:
DNA-directed RNA polymerase
transcription from RNA polymerase III promoter
positive regulation of type I interferon production
positive regulation of interferon-beta production
innate immune response
positive regulation of innate immune response
defense response to virus
immune system process
transcription, DNA-templated
biological_process
Performance Guarantee
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