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Proteintech
POLR3G Polyclonal Antibody
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Product Details
24701-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
POLR3G Fusion Protein Ag19872 (1-223 aa encoded by BC141649)
Conjugate
Form
Liquid
Concentration
0.63 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAGNKGRGR AAYTFNIEAV GFSKGEKLPD VVLKPPPLFP DTDYKPVPLK TGEGEEYMLA LKQELRETMK RMPYFIETPE ERQDIERYSK RYMKVYKEEW IPDWRRLPRE MMPRNKCKKA GPKPKKAKDA GKGTPLTNTE DVLKKMEELE KRGDGEKSDE ENEEKEGSKE KSKEGDDDDD DDAAEQEEYD EEEQEEENDY INSYFEDGDD FGADSDDNMD EATY (1-223 aa encoded by BC141649)
Target Information
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3G is a specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It may direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. It may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3G plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. POLR3G acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3G can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-directed RNA polymerase III 32 kDa polypeptide; DNA-directed RNA polymerase III subunit G; DNA-directed RNA polymerase III subunit RPC7; polymerase (RNA) III (DNA directed) polypeptide G (32kD); polymerase (RNA) III subunit G; RNA polymerase III 32 kDa apha subunit; RNA polymerase III 32 kDa subunit; RNA polymerase III subunit C7; RPC32; RPC32-alpha
Gene Aliases: POLR3G; RPC32; RPC7
UniProt ID: (Human) O15318
Entrez Gene ID: (Human) 10622
regulation of transcription from RNA polymerase III promoter
transcription initiation from RNA polymerase III promoter
cell proliferation
positive regulation of type I interferon production
positive regulation of interferon-beta production
innate immune response
positive regulation of innate immune response
defense response to virus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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