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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide made to an internal portion of the human POT1 protein sequence (between residues 200-300).|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris glycine with 0.15M NaCl|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The target sequence has 95% sequence homology with monkey, 82% sequence homology with rat, and 72% sequence homology with mouse.
Suggested positive control: HeLa nuclear extract, antigen standard for POT1 (transient overexpression lysate).
Telomere maintenance is essential for protection against changes in telomere length, which has been implicated in ageing and certain cancers. POT1 (protection of telomeres 1), a telomere regulator, is a single-stranded telomeric DNA-binding protein that controls telomerase-mediated telomere elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
POT 1; POT-1; POT1-like telomere end-binding protein; Protection of telomeres 1; protection of telomeres 1 homolog
CMM10; GLM9; HPOT1; POT1