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POU2F3 Polyclonal Antibody
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FIGURE: 1 / 3
POU2F3 Antibody (600-401-DR3) in ICC/IF
Immunofluorescence Microscopy of Rabbit anti-POU2F3 antibody. Tissue: rat brain. Primary antibody: POU2F3 antibody at 20 µg/mL. Secondary antibody: Fluorescein rabbit secondary antibody at 1:20,000. Localization: POU2F3 is nuclear. Staining: POU2F3 as red fluorescent signal.
Product Details
600-401-DR3
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-POU2F3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid peptide near the C-terminus of human POU2F3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 11-Oct; Epoc-1; FLJ40063; MGC126698; Oct-11; Octamer-binding protein 11; Octamer-binding transcription factor 11; OTF-11; POU domain transcription factor OCT11a; POU domain, class 2, transcription factor 3; Rov 1 pou-homeodomain protein; Skn-1a, Epoc-1; Transcription factor PLA-1; Transcription factor Skn-1; unnamed protein product
Gene Aliases: Epoc-1; Epoc1; OCT-11; Oct-11a; OCT11; OTF-11; OTF11; PLA-1; PLA1; POU2F3; Skin; Skin-1a; Skn-1; Skn-1a; Skn-li; Skn1
UniProt ID: (Human) Q9UKI9, (Rat) P42571, (Mouse) P31362
Entrez Gene ID: (Human) 25833, (Rat) 116544, (Mouse) 18988
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein dimerization activity
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
epidermis development
keratinocyte differentiation
wound healing
negative regulation by host of viral transcription
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
cell differentiation
transcription from RNA polymerase II promoter
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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