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Fabgennix

PP2A-alpha Polyclonal Antibody, FITC

View all (32) PP2A alpha antibodies

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Product Details

PP2A-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 410-486 on human Serine / Threonine-Protein Phosphatase 2A , B56- Alpha subunit.

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. The PP2A family comprises subfamily members PP2A alpha and PP2A beta. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B55-GAMMA; IMYPNO; IMYPNO1; Methyl-PPP2CA; MGC33570; phosphatase 2A; PP2A alpha; PP2A C terminal; PP2A L9; PP2A Leucine 9; PP2A-alpha; PPP2CA; PR52; PR55G; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase-2A-alpha; Replication protein C; RP-C; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; unnamed protein product

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Gene Aliases: HJS3; NEDLBA; Pp2a1; PP2Ac; PP2CA; PP2Calpha; PPP2CA; RP-C

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UniProt ID: (Human) P67775, (Rat) P63331

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Entrez Gene ID: (Human) 5515, (Rat) 24672

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Function(s)
phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein binding hydrolase activity metal ion binding protein heterodimerization activity tau protein binding GABA receptor binding RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity protein C-terminus binding enzyme binding protein kinase binding protein phosphatase binding protein domain specific binding protein complex binding protein kinase B binding ion channel binding protein dimerization activity protein phosphatase 2A binding protein antigen binding protein phosphatase
Process(es)
mitotic cell cycle regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter protein dephosphorylation mesoderm development response to lead ion negative regulation of epithelial to mesenchymal transition regulation of microtubule polymerization negative regulation of hippo signaling intracellular signal transduction peptidyl-threonine dephosphorylation regulation of growth T cell homeostasis regulation of cell differentiation meiotic cell cycle negative regulation of protein kinase B signaling negative regulation of canonical Wnt signaling pathway vascular endothelial cell response to oscillatory fluid shear stress RNA polymerase II transcription initiation surveillance positive regulation of NLRP3 inflammasome complex assembly negative regulation of glycolytic process through fructose-6-phosphate regulation of G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter regulation of protein phosphorylation negative regulation of protein phosphorylation cardiac ventricle development heart development regulation of receptor activity regulation of protein autophosphorylation cellular response to insulin stimulus positive regulation of protein phosphatase type 2A activity positive regulation of protein dephosphorylation regulation of protein catabolic process negative regulation of transcription factor import into nucleus positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process protein heterotrimerization cellular response to calcium ion cellular response to glucose stimulus cellular response to cytokine stimulus cellular response to ethanol cellular response to follicle-stimulating hormone stimulus cellular response to steroid hormone stimulus positive regulation of protein serine/threonine kinase activity negative regulation of calcium ion transmembrane transporter activity
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