Invitrogen

PP2A alpha/beta Polyclonal Antibody

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PP2A alpha/beta Polyclonal Antibody

Product Details

PA5-17980

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

10 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (EPHVTRRTPDYFL) corresponding to the C-terminus amino acids of PPP2CA / PPP2CB
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10986614

Product Specific Information

This antibody is predicted to react with bovine, canine, mouse, porcine, rabbit and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

Target Information

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: PP2A-alpha; PP2A-beta; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2, catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2,catalytic subunit alpha isozyme; protein phosphatase 2A alpha subunit; protein phosphatase 2A beta subunit; protein phosphatase 2A catalytic alpha subunit; protein phosphatase 2A catalytic subunit alpha isoform; protein phosphatase 2A catalytic subunit beta isoform; protein phosphatase 2A catalytic subunit, beta isoform; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase 2a, catalytic subunit, beta isoform; protein phosphatase type 2A catalytic subunit; protein phosphatase-2A-alpha; protein phosphatase-2A-beta; Replication protein C; RP C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; testicular tissue protein Li 146

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Gene Aliases: AI115466; D8Ertd766e; PP2A; Pp2a1; Pp2a2; PP2Abeta; PP2Ac; PP2CA; PP2Calpha; PP2CB; PPP2CA; PPP2CB; R75353; RP-C

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UniProt ID: (Human) P67775, (Pig) P67776, (Human) P62714, (Mouse) P63330, (Rat) P63331, (Rat) P62716, (Mouse) P62715

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Entrez Gene ID: (Human) 5515, (Pig) 397656, (Human) 5516, (Pig) 397136, (Mouse) 19052, (Rat) 24672, (Rat) 24673, (Mouse) 19053

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Function(s)
phosphoprotein phosphatase activity protein binding protein C-terminus binding metal ion binding GABA receptor binding protein serine/threonine phosphatase activity protein heterodimerization activity hydrolase activity enzyme binding protein kinase binding protein phosphatase binding protein domain specific binding protein complex binding protein kinase B binding ion channel binding protein dimerization activity tau protein binding protein phosphatase 2A binding protein antigen binding protein phosphatase
Process(es)
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay inactivation of MAPK activity regulation of DNA replication regulation of transcription, DNA-templated protein dephosphorylation ceramide metabolic process apoptotic process mitotic nuclear envelope reassembly mesoderm development RNA splicing response to organic substance negative regulation of epithelial to mesenchymal transition second-messenger-mediated signaling regulation of Wnt signaling pathway regulation of cell adhesion negative regulation of cell growth regulation of growth negative regulation of tyrosine phosphorylation of Stat3 protein regulation of cell differentiation meiotic cell cycle positive regulation of protein serine/threonine kinase activity peptidyl-threonine dephosphorylation apoptotic mitochondrial changes regulation of gene expression response to endoplasmic reticulum stress response to hydrogen peroxide proteasome-mediated ubiquitin-dependent protein catabolic process response to antibiotic negative regulation of transcription from RNA polymerase II promoter regulation of protein phosphorylation negative regulation of protein phosphorylation regulation of receptor activity regulation of protein autophosphorylation positive regulation of protein phosphatase type 2A activity positive regulation of protein dephosphorylation regulation of protein catabolic process negative regulation of transcription factor import into nucleus positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cell cycle protein heterotrimerization cellular response to glucose stimulus negative regulation of calcium ion transmembrane transporter activity cardiac ventricle development heart development cellular response to insulin stimulus cellular response to calcium ion cellular response to cytokine stimulus cellular response to ethanol cellular response to follicle-stimulating hormone stimulus cellular response to steroid hormone stimulus negative regulation of Ras protein signal transduction
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