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PP2CA Polyclonal Antibody
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Product Details
BS-4162R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PP2CA, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PPM1A (Protein phosphatase 1A) is also named as PPPM1A and belongs to the PP2C family. It is a serine/threonine protein phosphatase that is essential for regulating cellular stress responses in eukaryotes. PPM1A plays an important role in tumor suppression and that it negatively controls many signaling pathways which are critical for trophoblast invasion. This protein distributes in both the cytoplasm and nucleus of mammalian cells. It has 2 isoforms produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IA; Mpp alpha; PP2C-alpha; Protein phosphatase 1A; protein phosphatase 1A, magnesium dependent, alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform; Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform; unnamed protein product
Gene Aliases: 2310003C21Rik; 2900017D14Rik; AI427932; AU017636; MMPa-2; MPPa-1; PP2C-ALPHA; Pp2c1; PP2CA; PP2Calpha; PPM1A; PPPM1A
UniProt ID: (Human) P35813, (Mouse) P49443, (Rat) P20650
Entrez Gene ID: (Human) 5494, (Mouse) 19042, (Rat) 24666
magnesium ion binding
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein binding
hydrolase activity
manganese ion binding
calmodulin-dependent protein phosphatase activity
cation binding
metal ion binding
R-SMAD binding
catalytic activity
signal transducer activity
protein C-terminus binding
protein dephosphorylation
N-terminal protein myristoylation
negative regulation of SMAD protein complex assembly
Wnt signaling pathway
dephosphorylation
positive regulation of Wnt signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
peptidyl-threonine dephosphorylation
negative regulation of NF-kappaB import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription, DNA-templated
positive regulation of protein export from nucleus
cellular response to transforming growth factor beta stimulus
negative regulation of transcription from RNA polymerase II promoter
protein export from nucleus
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cell cycle
positive regulation of canonical Wnt signaling pathway
negative regulation of NIK/NF-kappaB signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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