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Invitrogen
PP5 Polyclonal Antibody
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Product Details
PA5-88227
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PPP5C (NP_0062381)
Conjugate
Form
Liquid
Concentration
1.12 mg/mL
Amount
112 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK LEDGKVTISF MKELMQWYKD QKKLHRKCAY; Positive Samples: U-87MG, Hela, H460, Mouse kidney, Mouse brain, Rat testis; Cellular Location: Cytoplasm, Membrane, Nucleus
Target Information
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANP receptor; FLJ36922; FLJ55954; OTTHUMP00000165834; PP-T; PP5; PPT; Protein phosphatase T; Serine/threonine-protein phosphatase 5; unnamed protein product
Gene Aliases: AU020526; PP5; PPP5; PPP5C; PPT
UniProt ID: (Human) P53041, (Rat) P53042, (Mouse) Q60676
Entrez Gene ID: (Human) 5536, (Rat) 65179, (Mouse) 19060
G-protein alpha-subunit binding
RNA binding
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein binding
ATP binding
microtubule binding
lipid binding
hydrolase activity
phosphatase activity
protein serine/threonine kinase inhibitor activity
Hsp70 protein binding
heat shock protein binding
mitogen-activated protein kinase kinase kinase binding
identical protein binding
ADP binding
macromolecular complex binding
metal ion binding
tau protein binding
Hsp90 protein binding
signal transducer activity
protein phosphatase
MAPK cascade
mitotic cell cycle
DNA repair
double-strand break repair
transcription, DNA-templated
cellular response to DNA damage stimulus
response to lead ion
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to morphine
negative regulation of MAPK cascade
peptidyl-serine dephosphorylation
cellular response to hydrogen peroxide
cellular response to cadmium ion
response to arachidonate
positive regulation of glucocorticoid receptor signaling pathway
negative regulation of protein phosphorylation
protein dephosphorylation
signal transduction
dephosphorylation
histone dephosphorylation
protein oligomerization
protein heterooligomerization
negative regulation of cell death
negative regulation of neuron death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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