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Invitrogen
PP5 Polyclonal Antibody
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FIGURE: 1 / 4
PP5 Antibody (PA5-98080) in ICC/IF
Immunofluorescent analysis of PP5 in A549 cells using a PP5 polyclonal antibody (Product # PA5-98080) at a dilution of 1:66. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were counter-stained with DAPI.
Product Details
PA5-98080
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Serine/threonine-protein phosphatase 5 protein (370-488AA)
Conjugate
Form
Liquid
Concentration
3.91 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANP receptor; FLJ36922; FLJ55954; OTTHUMP00000165834; PP-T; PP5; PPT; protein phosphatase 5, catalytic subunit; Protein phosphatase T; Serine/threonine-protein phosphatase 5
Gene Aliases: AU020526; PP5; PPP5; PPP5C; PPT
UniProt ID: (Human) P53041, (Mouse) Q60676
Entrez Gene ID: (Human) 5536, (Mouse) 19060
G-protein alpha-subunit binding
RNA binding
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
signal transducer activity
protein binding
ATP binding
microtubule binding
lipid binding
heat shock protein binding
identical protein binding
ADP binding
metal ion binding
hydrolase activity
protein phosphatase
MAPK cascade
negative regulation of protein phosphorylation
DNA repair
transcription, DNA-templated
protein dephosphorylation
mitotic nuclear division
response to lead ion
histone dephosphorylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to morphine
protein heterooligomerization
cellular response to hydrogen peroxide
cellular response to cadmium ion
negative regulation of neuron death
positive regulation of glucocorticoid receptor signaling pathway
signal transduction
dephosphorylation
protein oligomerization
negative regulation of cell death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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