Peptide sequence: QIYPFQRGFF CKDNSINYPY HDSTVTSTVL ILVGVGLPIS SIILGETLSV
Sequence homology: Guinea Pig: 86%; Human: 100%; Mouse: 79%; Rat: 93%
Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG). Subsequently, multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3.
Protein Aliases: 35 kDa PAP; Hic53; hydrogen peroxide inducible protein 53; Hydrogen peroxide-inducible protein 53; Lipid phosphate phosphohydrolase 1; lipid phosphate phosphohydrolase 1a; magnesium-independent type 2 phosphatidic acid phosphatase; mPAP; PAP-2a; PAP2-alpha; PAP2a; PAP2alpha2; PAPalpha1; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; phosphatidic acid phosphatase type 2A; phosphatidic acid phosphohydrolase type 2a; Phospholipid phosphatase 1; type-2 phosphatidic acid phosphatase alpha
Gene Aliases: Hic53; Hpic53; LLP1a; LPP-1; LPP1; mPAP; PAP-2a; PAP2; PAP2-alpha; PAP2A; PAP2a2; PLPP1; PPAP2A