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Rockland
PPAPDC2 Polyclonal Antibody
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FIGURE: 1 / 2
PPAPDC2 Antibody (600-401-DR8) in ICC/IF
Immunofluorescence Microscopy of PPAPDC2 antibody. Tissue: Raji cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: PPAPDC2 antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: PPAPDC2 is a membrane protein. Staining: PPAPDC2 as red fluorescent signal.
Product Details
600-401-DR8
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-PPAPDC2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 13 amino acid synthetic peptide from near the C-terminus human PPAPDC2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PPAPDC2 is a phosphatase that dephosphorylates Presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may have important role in innate immunity. PSDP is a bioactive lipid that rapidly remodels to PSMP upon cell activation. PPAPDC2 displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and has been identified in activated human neutrophil (PMN) extracts. It is widely expressed in human tissues. Recent studies shows PPAPDC2 is a functional isoprenoid diphosphate phosphatase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ46512; FLJ90191; Lipid phosphatase-related protein-B; LPRP-B; MGC15483; PA-PSP; phosphatidic acid phosphatase type 2 domain containing 2; Phosphatidic acid phosphatase type 2 domain-containing protein 2; Phospholipid phosphatase 6; polyisoprenoid diphosphate phosphatase type 1; Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; PPAP2 domain-containing protein 2; Presqualene diphosphate phosphatase; RP11-6J24.2; Type 1 polyisoprenoid diphosphate phosphatase
Gene Aliases: 4932443D16Rik; bA6J24.6; PDP1; PLPP6; PPAPDC2; PSDP
UniProt ID: (Human) Q8IY26, (Mouse) Q9D4F2, (Rat) Q66H88
Entrez Gene ID: (Human) 403313, (Mouse) 74411, (Rat) 619549
hydrolase activity
catalytic activity
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine/threonine phosphatase activity
JUN kinase phosphatase activity
phosphohistidine phosphatase activity
inositol bisphosphate phosphatase activity
MAP kinase tyrosine/serine/threonine phosphatase activity
inositol-1,3,4-trisphosphate 4-phosphatase activity
NADP phosphatase activity
transmembrane receptor protein phosphatase activity
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
inositol-4,5-bisphosphate 5-phosphatase activity
5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity
phosphatidylinositol-4-phosphate phosphatase activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
inositol phosphate phosphatase activity
inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
inositol-3,4-bisphosphate 4-phosphatase activity
inositol-1,3,4-trisphosphate 1-phosphatase activity
inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity
IDP phosphatase activity
phosphatase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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