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Invitrogen

PPAPDC2 Polyclonal Antibody

View all (4) PPAPDC2 antibodies

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PPAPDC2 Polyclonal Antibody

Product Details

PA5-20865

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunocytochemistry (ICC/IF)

20 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 13 amino acid peptide from near the carboxy terminus human PPAPDC2.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11157049

Product Specific Information

A suggested positive control is Raji cell lysate.

PA5-20865 can be used with blocking peptide PEP-0979.

Target Information

PPAPDC2 is a phosphatase that dephosphorylates Presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may have important role in innate immunity. PSDP is a bioactive lipid that rapidly remodels to PSMP upon cell activation. PPAPDC2 displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and has been identified in activated human neutrophil (PMN) extracts. It is widely expressed in human tissues. Recent studies shows PPAPDC2 is a functional isoprenoid diphosphate phosphatase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ46512; FLJ90191; Lipid phosphatase-related protein-B; LPRP-B; MGC15483; PA-PSP; phosphatidic acid phosphatase type 2 domain containing 2; Phosphatidic acid phosphatase type 2 domain-containing protein 2; Phospholipid phosphatase 6; polyisoprenoid diphosphate phosphatase type 1; Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; PPAP2 domain-containing protein 2; Presqualene diphosphate phosphatase; RP11-6J24.2; Type 1 polyisoprenoid diphosphate phosphatase; unnamed protein product

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Gene Aliases: 4932443D16Rik; bA6J24.6; LPRP-B; PA-PSP; PDP1; PLPP6; PPAPDC2; PSDP

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UniProt ID: (Human) Q8IY26, (Mouse) Q9D4F2, (Rat) Q66H88

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Entrez Gene ID: (Human) 403313, (Mouse) 74411, (Rat) 619549

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Function(s)
protein binding phosphatidate phosphatase activity hydrolase activity lyase activity sphingosine-1-phosphate phosphatase activity lipid phosphatase activity lysophosphatidic acid phosphatase activity isoprenoid diphosphate phosphatase activity catalytic activity protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity JUN kinase phosphatase activity phosphohistidine phosphatase activity inositol bisphosphate phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity inositol-1,3,4-trisphosphate 4-phosphatase activity NADP phosphatase activity transmembrane receptor protein phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity inositol-4,5-bisphosphate 5-phosphatase activity 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity phosphatidylinositol-4-phosphate phosphatase activity phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity inositol phosphate phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity inositol-3,4-bisphosphate 4-phosphatase activity inositol-1,3,4-trisphosphate 1-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity IDP phosphatase activity phosphatase
Process(es)
immune system process lipid metabolic process cholesterol biosynthetic process isoprenoid metabolic process protein prenylation geranyl diphosphate metabolic process innate immune response farnesyl diphosphate catabolic process phospholipid dephosphorylation geranylgeranyl diphosphate catabolic process positive regulation of neutrophil activation biological_process metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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