A suggested positive control is Raji cell lysate.
PA5-20865 can be used with blocking peptide PEP-0979.
PPAPDC2 is a phosphatase that dephosphorylates Presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may have important role in innate immunity. PSDP is a bioactive lipid that rapidly remodels to PSMP upon cell activation. PPAPDC2 displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and has been identified in activated human neutrophil (PMN) extracts. It is widely expressed in human tissues. Recent studies shows PPAPDC2 is a functional isoprenoid diphosphate phosphatase.
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Protein Aliases: FLJ46512; FLJ90191; MGC15483; phosphatidic acid phosphatase type 2 domain containing 2; Phosphatidic acid phosphatase type 2 domain-containing protein 2; Phospholipid phosphatase 6; polyisoprenoid diphosphate phosphatase type 1; PPAP2 domain-containing protein 2; Presqualene diphosphate phosphatase; RP11-6J24.2
Gene Aliases: 4932443D16Rik; bA6J24.6; PDP1; PLPP6; PPAPDC2; PSDP