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Rockland
PPAR Delta Polyclonal Antibody
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FIGURE: 1 / 3
PPAR Delta Antibody (600-401-420) in IHC
Immunohistochemistry of Rabbit Anti-PPAR delta (N terminal specific). Antigen Retrieval: HIER pH 6.2. Neg Ctrl: (Right-40X) Normal rabbit IgG on heart striated muscle, pH6.2. Staining: (left top-low mag, left lower 20X) Diffuse cytoplasmatic positivity for PPAR delta in human myocardiocytes at 1:500.
Product Details
600-401-420
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-PPAR delta antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of mouse PPAR delta.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Directed against mouse PPAR delta protein. A BLAST analysis was used to suggest reactivity with this protein from mouse and rat sources based on 100% homology for the immunogen sequence. Cross-reactivity with PPAR delta protein from human, chimpanzee and rabbit may occur as this sequence shows 85% homology with the protein from these sources. Cross-reactivity with PPAR delta homologues from other sources has not been determined. No reactivity is expected against other subtypes of PPAR.
Target Information
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC3931; NUC1; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor, delta; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; PPARdelta/beta
Gene Aliases: Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta; PPAR[b]; Pparb; Pparb/d; Ppard; PPARdelta
UniProt ID: (Mouse) P35396
Entrez Gene ID: (Rat) 25682, (Mouse) 19015
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
fatty acid binding
drug binding
zinc ion binding
lipid binding
sequence-specific DNA binding
protein heterodimerization activity
NF-kappaB binding
linoleic acid binding
enzyme activator activity
prostacyclin receptor activity
metal ion binding
retinoid X receptor binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
placenta development
proteoglycan metabolic process
lipid metabolic process
fatty acid beta-oxidation
vitamin A metabolic process
heart development
embryo implantation
cell proliferation
positive regulation of cell proliferation
axon ensheathment
phospholipid biosynthetic process
mRNA transcription
response to glucose
response to organic substance
positive regulation of phosphatidylinositol 3-kinase signaling
response to activity
negative regulation of smooth muscle cell migration
fatty acid transport
fatty acid oxidation
cell differentiation
negative regulation of cell growth
intracellular receptor signaling pathway
cell-substrate adhesion
positive regulation of insulin secretion
negative regulation of collagen biosynthetic process
response to vitamin A
wound healing
regulation of cell proliferation
negative regulation of apoptotic process
steroid hormone mediated signaling pathway
keratinocyte proliferation
regulation of fat cell differentiation
positive regulation of epidermis development
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
decidualization
negative regulation of smooth muscle cell proliferation
negative regulation of epithelial cell proliferation
negative regulation of inflammatory response
keratinocyte migration
adipose tissue development
cellular response to hypoxia
apoptotic signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
apoptotic process
G-protein coupled receptor signaling pathway
epidermis development
cellular process
anagen
positive regulation of catalytic activity
regulation of insulin secretion
cellular response to lipopolysaccharide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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