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Invitrogen
PPARGC1A Polyclonal Antibody
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Product Details
PA5-144904
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 300-381.
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PPHKANQDNP FRASPKLKSS CKTVVPPPSK KPRYSESSGT QGNNSTKKGP EQSELYAQLS KSSVLTGGHE ERKTKRPSLR LF
Antigen sequence identity: Mouse 87%; Rat 88%
Target Information
PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it's interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: L-PGC-1alpha; Ligand effect modulator 6; ligand effect modulator-6; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; pgc-1 alpha; PGC-1-alpha; PPAR gamma coactivator variant form; PPARAGCIalpha; PPARgamma coactivator 1alpha; PPARGC-1-alpha; transcriptional coactivator; transcriptional coactivator; PGC-1; unnamed protein product
Gene Aliases: LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; PGC1; PGC1A; PPARGC1; PPARGC1A
UniProt ID: (Human) Q9UBK2
Entrez Gene ID: (Human) 10891
nucleic acid binding
DNA binding
transcription cofactor activity
transcription coactivator activity
RNA binding
protein binding
ligand-dependent nuclear receptor binding
chromatin DNA binding
ubiquitin protein ligase binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
lncRNA binding
DNA-binding transcription factor binding
temperature homeostasis
cellular glucose homeostasis
response to dietary excess
gluconeogenesis
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
mRNA processing
mitochondrion organization
digestion
RNA splicing
positive regulation of gene expression
response to muscle activity
fatty acid oxidation
respiratory electron transport chain
developmental process
circadian regulation of gene expression
cellular response to oxidative stress
homeostatic process
response to starvation
regulation of circadian rhythm
negative regulation of neuron apoptotic process
cellular respiration
positive regulation of gluconeogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
rhythmic process
negative regulation of smooth muscle cell proliferation
protein stabilization
brown fat cell differentiation
neuron apoptotic process
adipose tissue development
protein-containing complex assembly
energy homeostasis
positive regulation of cold-induced thermogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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