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Proteintech
PPARGC1B Polyclonal Antibody
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Product Details
22378-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Fish,
Goat,
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPARGC1B Fusion Protein Ag17566 (1-350 aa encoded by BC132971)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAGNDCGAL LDEELSSFFL NYLADTQGGG SGEEQLYADF PELDLSQLDA SDFDSATCFG ELQWCPENSE TEPNQYSPDD SELFQIDSEN EALLAELTKT LDDIPEDDVG LAAFPALDGG DALSCTSASP APSSAPPSPA PEKPSAPAPE VDELSLLQKL LLATSYPTSS SDTQKEGTAW RQAGLRSKSQ RPCVKADSTQ DKKAPMMQSQ SRSCTELHKH LTSAQCCLQD RGLQPPCLQS PRLPAKEDKE PGEDCPSPQP APASPRDSLA LGRADPGAPV SQEDMQAMVQ LIRYMHTYCL PQRKLPPQTP EPLPKACSNP SQQVRSRPWS RHHSKASWAE FSILRELLAQ D (1-350 aa encoded by BC132971)
Target Information
PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ERR ligand 1; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; pgc-1 beta; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1beta; PGC-1beta/ERRL1; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-beta; PPARgamma coactivator 1 beta; PPARGC-1-beta
Gene Aliases: 4631412G21Rik; ERRL1; PERC; PGC-1(beta); PGC1; PGC1B; PPARGC1; PPARGC1B
UniProt ID: (Human) Q86YN6, (Mouse) Q8VHJ7
Entrez Gene ID: (Human) 133522, (Mouse) 170826
nucleotide binding
RNA polymerase II transcription cofactor activity
RNA binding
transcription factor binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
receptor activator activity
AF-2 domain binding
nucleic acid binding
protein binding
transcription cofactor
ossification
regulation of transcription, DNA-templated
transcription from mitochondrial promoter
mitochondrion organization
actin filament organization
positive regulation of alkaline phosphatase activity
intracellular estrogen receptor signaling pathway
cellular response to reactive oxygen species
positive regulation of phosphorylation
positive regulation of osteoclast differentiation
positive regulation of bone resorption
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
response to cAMP
bone trabecula formation
positive regulation of receptor activity
transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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