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Invitrogen
PPARGC1B Polyclonal Antibody
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FIGURE: 1 / 1
PPARGC1B Antibody (PA5-85594) in WB
Western Blot using PPARGC1B Polyclonal Antibody (Product # PA5-85594). Rat tissue extract (50 µg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with PGC-1 beta antibody PPARGC1B Polyclonal Antibody (Product # PA5-85594) diluted at 1:500.
Product Details
PA5-85594
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PGC1 beta. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (82%), Rat (83%).
Positive Control: rat heart.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PERC; PERC-s; lacks one estrogen receptor interaction domain; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; pgc-1 beta; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC1beta-1a; PGC1beta-1b; PGC1beta-2a; PGC1beta-2b; PPAR-gamma coactivator 1-beta; PPARAGCIbeta; PPARgamma coactivator 1 beta; PPARGC-1-beta; unnamed protein product
Gene Aliases: ERRL1; PERC; PGC-1(beta); PGC1; PGC1B; PGC1beta; PPARGC1; PPARGC1B
UniProt ID: (Human) Q86YN6, (Rat) Q811R2
Entrez Gene ID: (Human) 133522, (Rat) 291567
nucleic acid binding
transcription cofactor activity
transcription coactivator activity
RNA binding
protein binding
estrogen receptor binding
AF-2 domain binding
nucleotide binding
RNA polymerase II transcription cofactor activity
molecular_function
transcription factor binding
ligand-dependent nuclear receptor transcription coactivator activity
receptor activator activity
transcription cofactor
regulation of transcription, DNA-templated
intracellular estrogen receptor signaling pathway
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
energy homeostasis
positive regulation of cold-induced thermogenesis
ossification
transcription from RNA polymerase II promoter
transcription from mitochondrial promoter
actin filament organization
positive regulation of alkaline phosphatase activity
cellular response to reactive oxygen species
positive regulation of phosphorylation
positive regulation of bone resorption
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
response to cAMP
bone trabecula formation
positive regulation of receptor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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