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Proteintech
PPM1A Polyclonal Antibody
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Product Details
12961-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPM1A Fusion Protein Ag3645 (49-383 aa encoded by BC026691)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GLESWSFFA VYDGHAGSQV AKYCCEHLLD HITNNQDFKG SAGAPSVENV KNGIRTGFLE IDEHMRVMSE KKHGADRSGS TAVGVLISPQ HTYFINCGDS RGLLCRNRKV HFFTQDHKPS NPLEKERIQN AGGSVMIQRV NGSLAVSRAL GDFDYKCVHG KGPTEQLVSP EPEVHDIERS EEDDQFIILA CDGIWDVMGN EELCDFVRSR LEVTDDLEKV CNEVVDTCLY KGSRDNMSVI LICFPNAPKV SPEAVKKEAE LDKYLECRVE EIIKKQGEGV PDLVHVMRTL ASENIPSLPP GGELASKRNV IEAVYNRLNP YKNDDTDSTS TDDMW (49-383 aa encoded by B C026691)
Target Information
PPM1A (Protein phosphatase 1A) is also named as PPPM1A and belongs to the PP2C family. It is a serine/threonine protein phosphatase that is essential for regulating cellular stress responses in eukaryotes. PPM1A plays an important role in tumor suppression and that it negatively controls many signaling pathways which are critical for trophoblast invasion. This protein distributes in both the cytoplasm and nucleus of mammalian cells. It has 2 isoforms produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IA; Mpp alpha; PP2C-alpha; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 1A, magnesium dependent, alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform; Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform; protein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene Aliases: 2310003C21Rik; 2900017D14Rik; AI427932; AU017636; MMPa-2; MPPa-1; PP2C-ALPHA; Pp2c1; PP2CA; PP2Calpha; PPM1A; PPPM1A
UniProt ID: (Human) P35813, (Mouse) P49443, (Rat) P20650
Entrez Gene ID: (Human) 5494, (Mouse) 19042, (Rat) 24666
magnesium ion binding
protein serine/threonine phosphatase activity
signal transducer activity
protein binding
manganese ion binding
calmodulin-dependent protein phosphatase activity
R-SMAD binding
catalytic activity
phosphoprotein phosphatase activity
protein C-terminus binding
hydrolase activity
metal ion binding
protein dephosphorylation
N-terminal protein myristoylation
negative regulation of SMAD protein complex assembly
Wnt signaling pathway
dephosphorylation
positive regulation of Wnt signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
peptidyl-threonine dephosphorylation
negative regulation of NF-kappaB import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription, DNA-templated
positive regulation of protein export from nucleus
cellular response to transforming growth factor beta stimulus
negative regulation of transcription from RNA polymerase II promoter
cell cycle arrest
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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