Immunogen sequence: GQGNGLRYGL SSMQGWRVEM EDAHTAVIGL PSGLESWSFF AVYDGHAGSQ VAKYCCEHLL DHITNNQDFK GSAGAPSVEN VKNGIRTGFL EIDEHMRVMS EKKHGADRSG STAVGVLISP QHTYFINCGD SRGLLCRNRK VHFFTQDHKP SGAPHR
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC9201; PP2C-alpha; PP2Calpha; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; protein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene Aliases: PP2C-ALPHA; PP2CA; PP2Calpha; PPM1A; PPPM1A
UniProt ID: (Human) P35813
Entrez Gene ID: (Human) 5494