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Proteintech
PPM1B Polyclonal Antibody
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Product Details
13193-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPM1B Fusion Protein Ag3871 (1-192 aa encoded by BC012002)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSIVLVCFS NAPKVSDEAV KKDSELDKHL ESRVEEIMEK SGEEGMPDLA HVMRILSAEN IPNLPPGGGL AGKRNVIEAV YSRLNPHRES DGASDEAEES GSQGKLVEAL RQMRINHRGN YRQLLEEMLT SYRLAKVEGE ESPAEPAATA TSSNSDAGNP VTMQESHTES ESGLAELDSS NEDAGTKMSG EKI (1-192 aa encoded by BC012002)
Target Information
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PP2C-beta; Protein phosphatase 1B; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; Protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase, Mg2+/Mn2+ dependent, 1B; Ser/Thr protein phosphatase type 2C beta 2 isoform
Gene Aliases: PP2C-beta; PP2C-beta-X; Pp2c2; PP2CB; PP2CBETA; PPC2BETAX; PPM1B; Pppm1b
UniProt ID: (Human) O75688, (Mouse) P36993
Entrez Gene ID: (Human) 5495, (Mouse) 19043
protein dephosphorylation
N-terminal protein myristoylation
negative regulation of interferon-beta production
peptidyl-threonine dephosphorylation
negative regulation of NF-kappaB import into nucleus
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of defense response to virus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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