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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 255 of Human PPM1B|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ChIP assay (ChIP)||Assay-Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29263 targets PPM1B in IF, IHC (P), ChIP and WB applications and shows reactivity with Human samples.
The PA5-29263 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 255 of Human PPM1B.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
beta isoform; magnesium-dependent; PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX; protein phosphatase 1B; protein phosphatase 1B (formerly 2C); protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase, Mg2+/Mn2+ dependent, 1B; Ser/Thr protein phosphatase type 2C beta 2 isoform
PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX; PPM1B