Immunogen sequence: KRNVIEAVYS RLNPHRESDG ASDEAEESGS QGKLVEALRQ MRINHRGNYR QLLEEMLTSY RLAKVEGEES PAEPAATATS SNSDAGNPVT MQESHTESES GLAEL
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
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Protein Aliases: PP2C-beta; PP2CB; PP2CBETA; PPC2BETAX; Protein phosphatase 1B; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; Protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase, Mg2+/Mn2+ dependent, 1B; Ser/Thr protein phosphatase type 2C beta 2 isoform
Gene Aliases: PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX; PPM1B
UniProt ID: (Human) O75688
Entrez Gene ID: (Human) 5495