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Product Details
17020-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPM1F Fusion Protein Ag10186 (104-453 aa encoded by BC071989)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EEEEDDDEE KAPVTLLDAQ SLAQSFFNRL WEVAGQWQKQ VPLAARASQR QWLVSIHAIR NTRRKMEDRH VSLPSFNQLF GLSDPVNRAY FAVFDGHGGV DAARYAAVHV HTNAARQPEL PTDPEGALRE AFRRTDQMFL RKAKRERLQS GTTGVCALIA GATLHVAWLG DSQVILVQQG QVVKLMEPHR PERQDEKARI EALGGFVSHM DCWRVNGTLA VSRAIGDVFQ KPYVSGEADA ASRALTGSED YLLLACDGFF DVVPHQEVVG LVQSHLTRQQ GSGLRVAEEL VAAARERGSH DNITVMVVFL RDPQELLEGG NQGEGDPQAE GRRQDLPSSL PEPETQAPPR S (104-453 aa encoded by BC071989)
Target Information
PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ca(2+)/calmodulin-dependent protein kinase phosphatase; calcium/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; hFem-2; Partner of PIX 2; partner of PIX2; PP2C phosphatase; Protein fem-2 homolog; Protein phosphatase 1F; protein phosphatase 1F (PP2C domain containing); protein phosphatase, Mg2+/Mn2+ dependent, 1F
Gene Aliases: 1110021B16Rik; 4933427B07Rik; CAMKP; CaMKPase; FEM-2; hFEM-2; KIAA0015; mKIAA0015; POPX2; PPM1F
UniProt ID: (Human) P49593, (Mouse) Q8CGA0, (Rat) Q9WVR7
Entrez Gene ID: (Human) 9647, (Mouse) 68606, (Rat) 287931
negative regulation of protein kinase activity
positive regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of cell-substrate adhesion
histone dephosphorylation
negative regulation of peptidyl-serine phosphorylation
cellular response to drug
peptidyl-threonine dephosphorylation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of protein kinase activity by regulation of protein phosphorylation
negative regulation of transcription, DNA-templated
positive regulation of growth
positive regulation of chemotaxis
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
intrinsic apoptotic signaling pathway
protein dephosphorylation
apoptotic process
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