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Product Details
55129-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M sodium bicarbonate/0.1M glycine, pH 7.3, with 50% glycerol, 0.1M glycine
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to PPP1R9B.
Target Information
Protein phosphatase 1 regulatory subunit 9B (PPP1R9B), also known as Neurabin II or spinophilin, is a gene located on chromosome 17q21.32 that encodes a regulatory protein predominantly expressed in the brain. PPP1R9B is involved in modulating the activity of protein phosphatase 1 (PP1), a crucial enzyme in cellular signaling pathways responsible for dephosphorylation of target proteins. Spinophilin functions by anchoring PP1 to specific subcellular locations, such as synaptic sites, thereby influencing synaptic plasticity, neurotransmission, and signal transduction. This protein is integral to the maintenance and modulation of excitatory synapses, playing a role in cognitive processes including learning and memory. Alterations in PPP1R9B expression or function have been associated with neuropsychiatric disorders and cancer, reflecting its importance in neuronal integrity and its potential role in tumorigenesis. Research into PPP1R9B continues to explore its therapeutic potential in neurological disorders and its utility in understanding phosphatase-related cellular processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: neurabin II; Neurabin-2; Neurabin-II; Protein phosphatase 1 regulatory subunit 9B; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin; Spinophilin
Gene Aliases: PPP1R6; PPP1R9; PPP1R9B; SPINO; SPL; Spn
UniProt ID: (Human) Q96SB3, (Mouse) Q6R891
Entrez Gene ID: (Human) 84687, (Mouse) 217124
regulation of protein phosphorylation
protein phosphorylation
actin filament organization
multicellular organism development
nervous system development
dendrite development
cell migration
calcium-mediated signaling
actin cytoskeleton organization
cell differentiation
negative regulation of cell growth
negative regulation of phosphoprotein phosphatase activity
regulation of cell proliferation
filopodium assembly
modulation of synaptic transmission
cellular response to morphine
cellular response to light stimulus
positive regulation of establishment of protein localization to plasma membrane
protein localization to actin cytoskeleton
positive regulation of cellular protein localization
regulation of opioid receptor signaling pathway
regulation of cell growth by extracellular stimulus
cell cycle arrest
regulation of exit from mitosis
RNA splicing
neuron projection development
negative regulation of catalytic activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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