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Invitrogen
PPP1R9B Polyclonal Antibody
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FIGURE: 1 / 5
PPP1R9B Antibody (PA5-99795) in ICC/IF
Immunocytochemistry analysis of PPP1R9B in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with PPP1R9B polyclonal antibody (Product # PA5-99795) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-99795
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PPP1R9B(Accession Q96SB3), corresponding to amino acid residues L686-D736.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NEB2.
Target Information
Protein phosphatase 1 regulatory subunit 9B (PPP1R9B), also known as Neurabin II or spinophilin, is a gene located on chromosome 17q21.32 that encodes a regulatory protein predominantly expressed in the brain. PPP1R9B is involved in modulating the activity of protein phosphatase 1 (PP1), a crucial enzyme in cellular signaling pathways responsible for dephosphorylation of target proteins. Spinophilin functions by anchoring PP1 to specific subcellular locations, such as synaptic sites, thereby influencing synaptic plasticity, neurotransmission, and signal transduction. This protein is integral to the maintenance and modulation of excitatory synapses, playing a role in cognitive processes including learning and memory. Alterations in PPP1R9B expression or function have been associated with neuropsychiatric disorders and cancer, reflecting its importance in neuronal integrity and its potential role in tumorigenesis. Research into PPP1R9B continues to explore its therapeutic potential in neurological disorders and its utility in understanding phosphatase-related cellular processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: neurabin 2; neurabin II; Neurabin-2; Neurabin-II; Neural tissue-specific F-actin-binding protein II; nuerabin 2; p130; PP1bp134; Protein phosphatase 1 regulatory subunit 9B; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin; Spinophilin; unnamed protein product
Gene Aliases: Neb2; PPP1R6; PPP1R9; PPP1R9B; SPINO; SPL; Spn
UniProt ID: (Human) Q96SB3, (Rat) O35274, (Mouse) Q6R891
Entrez Gene ID: (Human) 84687, (Rat) 84686, (Mouse) 217124
regulation of protein phosphorylation
actin filament organization
dendrite development
cell migration
calcium-mediated signaling
negative regulation of cell growth
regulation of cell proliferation
filopodium assembly
modulation of synaptic transmission
cellular response to morphine
regulation of opioid receptor signaling pathway
protein phosphorylation
multicellular organism development
nervous system development
actin cytoskeleton organization
cell differentiation
negative regulation of phosphoprotein phosphatase activity
cellular response to light stimulus
positive regulation of establishment of protein localization to plasma membrane
protein localization to actin cytoskeleton
positive regulation of cellular protein localization
regulation of cell growth by extracellular stimulus
response to amphetamine
developmental process involved in reproduction
regulation of exit from mitosis
learning
RNA splicing
response to xenobiotic stimulus
hippocampus development
cerebral cortex development
actin filament depolymerization
neuron projection development
response to estradiol
response to prostaglandin E
response to nicotine
response to immobilization stress
response to amino acid
response to steroid hormone
regulation of cell cycle
male mating behavior
reproductive system development
cellular response to epidermal growth factor stimulus
cellular response to estradiol stimulus
cellular response to xenobiotic stimulus
regulation of postsynapse assembly
cellular response to peptide
positive regulation of protein localization to plasma membrane
positive regulation of protein localization to actin cortical patch
response to kainic acid
response to L-phenylalanine derivative
protein localization to cell periphery
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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