Proteintech

PPP2R1A Polyclonal Antibody

PPP2R1A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PPP2R1A Antibody (15882-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human ovary tumor using 15882-1-AP (PPP2R1A antibody) at dilution of 1:50 (under 40x lens).

PPP2R1A Antibody in Immunoprecipitation (IP)

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Product Details

15882-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PPP2R1A Fusion Protein Ag8661 (239-589 aa encoded by BC001537)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DLEALVMPT LRQAAEDKSW RVRYMVADKF TELQKAVGPE ITKTDLVPAF QNLMKDCEAE VRAAASHKVK EFCENLSADC RENVIMSQIL PCIKELVSDA NQHVKSALAS VIMGLSPILG KDNTIEHLLP LFLAQLKDEC PEVRLNIISN LDCVNEVIGI RQLSQSLLPA IVELAEDAKW RVRLAIIEYM PLLAGQLGVE FFDEKLNSLC MAWLVDHVYA IREAATSNLK KLVEKFGKEW AHATIIPKVL AMSGDPNYLH RMTTLFCINV LSEVCGQDIT TKHMLPTVLR MAGDPVANVR FNVAKSLQKI GPILDNSTLQ SEVKPILEKL TQDQDVDVKY FAQEALTVLS LA (239-589 aa encoded by BC001537)

Target Information

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates.

Developmental cell

Fu Y,Jia X,Yuan J,Yang Y,Zhang T,Yu Q,Zhou J,Wang T

Mon Mar 13 00:00:00 UTC 2023

Venlafaxine antagonizes the noradrenaline-promoted colon cancer progression by inhibiting the norepinephrine transporter.

Cell death discovery

Zhang H,Han J,Zhang J,Miao J,Li F,Tang K,Zhou K,Duan B,Li W,Cheng J,Sun Y,Hou N,Huang C

Mon May 08 00:00:00 UTC 2023

TurboID Screening of the OmpP2 Protein Reveals Host Proteins Involved in Recognition and Phagocytosis of Glaesserella parasuis by iPAM Cells.

Microbiology spectrum

Jiang C,Ma N,Cao H,Zeng W,Ren J,Hu Y,Zhou J,Zhang M,Li C,Lang Y,Li W,He Q

Wed Oct 26 00:00:00 UTC 2022

TurboID Screening of the OmpP2 Protein Reveals Host Proteins Involved in Recognition and Phagocytosis of Glaesserella parasuis by iPAM Cells.

Microbiology spectrum

Jiang C,Ma N,Cao H,Zeng W,Ren J,Hu Y,Zhou J,Zhang M,Li C,Lang Y,Li W,He Q

Wed Oct 26 00:00:00 UTC 2022

TurboID Screening of the OmpP2 Protein Reveals Host Proteins Involved in Recognition and Phagocytosis of Glaesserella parasuis by iPAM Cells.

Microbiology spectrum

Jiang C,Ma N,Cao H,Zeng W,Ren J,Hu Y,Zhou J,Zhang M,Li C,Lang Y,Li W,He Q

Wed Oct 26 00:00:00 UTC 2022

TurboID Screening of the OmpP2 Protein Reveals Host Proteins Involved in Recognition and Phagocytosis of Glaesserella parasuis by iPAM Cells.

Microbiology spectrum

Jiang C,Ma N,Cao H,Zeng W,Ren J,Hu Y,Zhou J,Zhang M,Li C,Lang Y,Li W,He Q

Wed Oct 26 00:00:00 UTC 2022

SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape.

Molecular cell

Hu S,Peng L,Xu C,Wang Z,Song A,Chen FX

Thu Nov 04 00:00:00 UTC 2021

BRG1 Activates PR65A Transcription to Regulate NO Bioavailability in Vascular Endothelial Cells.

Frontiers in cell and developmental biology

Chen B,Zhao Q,Xu T,Yu L,Zhuo L,Yang Y,Xu Y

Mon Sep 28 00:00:00 UTC 2020

Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.

Science (New York, N.Y.)

Zheng H,Qi Y,Hu S,Cao X,Xu C,Yin Z,Chen X,Li Y,Liu W,Li J,Wang J,Wei G,Liang K,Chen FX,Xu Y

Fri Nov 27 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: alpha isoform of regulatory subunit A, protein phosphatase 2; Medium tumor antigen-associated 61 kDa protein; MGC786; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha; PP2Ac; PP2CA; PP2Calpha; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; protein phosphatase 2 regulatory subunit A, alpha; protein phosphatase 2, regulatory subunit A, alpha; protein phosphatase PP2A; RP-C; serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform; serine/threonine protein phosphatase A subunit type 2A; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; testicular secretory protein Li 1

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Gene Aliases: 6330556D22Rik; MRD36; PP2A; PP2A-Aalpha; PP2AAALPHA; PPP2R1A; PR65; PR65A

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UniProt ID: (Human) P30153, (Mouse) Q76MZ3

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Entrez Gene ID: (Human) 5518, (Mouse) 51792, (Rat) 117281

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Function(s)

antigen binding protein serine/threonine phosphatase activity protein binding protein phosphatase type 2A regulator activity protein heterodimerization activity phosphatase modulator

Process(es)

G2/M transition of mitotic cell cycle nuclear-transcribed mRNA catabolic process, nonsense-mediated decay inactivation of MAPK activity regulation of DNA replication regulation of transcription, DNA-templated protein complex assembly protein dephosphorylation ceramide metabolic process apoptotic process chromosome segregation mitotic nuclear envelope reassembly female meiotic division RNA splicing response to organic substance second-messenger-mediated signaling regulation of Wnt signaling pathway regulation of cell adhesion negative regulation of cell growth regulation of protein phosphatase type 2A activity regulation of growth negative regulation of tyrosine phosphorylation of Stat3 protein regulation of cell differentiation meiotic spindle elongation mitotic sister chromatid separation meiotic sister chromatid cohesion, centromeric peptidyl-serine dephosphorylation regulation of meiotic cell cycle process involved in oocyte maturation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PPP2R1A Polyclonal Antibody

PPP2R1A Antibody (15882-1-AP) in IHC (P)

Product Details

15882-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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