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Proteintech
PPP2R1A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
15882-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPP2R1A Fusion Protein Ag8661 (239-589 aa encoded by BC001537)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.16 mg/mL
Amount
24 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DLEALVMPT LRQAAEDKSW RVRYMVADKF TELQKAVGPE ITKTDLVPAF QNLMKDCEAE VRAAASHKVK EFCENLSADC RENVIMSQIL PCIKELVSDA NQHVKSALAS VIMGLSPILG KDNTIEHLLP LFLAQLKDEC PEVRLNIISN LDCVNEVIGI RQLSQSLLPA IVELAEDAKW RVRLAIIEYM PLLAGQLGVE FFDEKLNSLC MAWLVDHVYA IREAATSNLK KLVEKFGKEW AHATIIPKVL AMSGDPNYLH RMTTLFCINV LSEVCGQDIT TKHMLPTVLR MAGDPVANVR FNVAKSLQKI GPILDNSTLQ SEVKPILEKL TQDQDVDVKY FAQEALTVLS LA (239-589 aa encoded by BC001537)
Target Information
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: medium tumor antigen-associated 61 KDA protein; MGC786; PP2Ac; PP2CA; PP2Calpha; PPP2R1A; protein phosphatase 2, regulatory subunit A, alpha; protein phosphatase PP2A; RP-C; serine/threonine protein phosphatase A subunit type 2A; testicular secretory protein Li 1; unnamed protein product
Gene Aliases: 6330556D22Rik; HJS2; MRD36; PP2A; PP2A-Aalpha; PP2AA; PP2AAALPHA; PR65; PR65A
UniProt ID: (Human) P30153, (Mouse) Q76MZ3
Entrez Gene ID: (Human) 5518, (Mouse) 51792, (Rat) 117281
chromosome segregation
snRNA processing
regulation of transcription elongation from RNA polymerase II promoter
regulation of hippo signaling
negative regulation of hippo signaling
intracellular signal transduction
regulation of growth
T cell homeostasis
regulation of cell differentiation
spindle assembly
meiotic sister chromatid cohesion, centromeric
negative regulation of protein kinase B signaling
protein-containing complex assembly
RNA polymerase II transcription initiation surveillance
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
female meiotic division
meiotic spindle elongation
mitotic sister chromatid separation
peptidyl-serine dephosphorylation
regulation of meiotic cell cycle process involved in oocyte maturation
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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