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Product Details
29237-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPP2R2B/A/C/D fusion protein Ag30757
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SHSGRYIMTR DYLTVKVWDL NMENRPIETY QVHDYLRSKL CSLYENDCIF DKFECVWNGS DSVIMTGSYN NFFRMFDRNT KRDVTLEASR ENSKPRAILK PRKVCVGGKR RKDEISVDSL DFSKKILHTA WHPSENIIAV AATNNLYIFQ DKVN
Target Information
The genes PPP2R2B, PPP2R2A, PPP2R2C, and PPP2R2D encode different regulatory subunits of protein phosphatase 2 (PP2A), a major serine/threonine phosphatase implicated in various cellular processes. PPP2R2B is located on chromosome 5q32 and has multiple alternatively spliced transcripts, playing a significant role in cancer prognosis and immune evasion (ScienceDirect). PPP2R2A, encoding the B55 alpha subunit, is frequently deleted in prostate adenocarcinomas, correlating with poor prognosis (PubMed). PPP2R2C, encoding the B55 gamma isoform, is shown to suppress glioma cell proliferation, acting as a tumor suppressor (ScienceDirect). PPP2R2D is involved in T-cell regulation and cancer cell proliferation, with overexpression linked to increased mTOR activity and impact on IL-2 production (PubMed). Collectively, these genes highlight the complexity and critical regulatory roles of PP2A subunits in cell signaling and disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BRbeta B-regulatory subunit of protein phosphatase 2A; gamma isoform of regulatory subunit B55, protein phosphatase 2; IMYPNO1; phosphoprotein phosphatase 2A BR gamma regulatory chain; PP2A subunit B isoform alpha; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform B55-beta; PP2A subunit B isoform B55-delta; PP2A subunit B isoform B55-gamma; PP2A subunit B isoform beta; PP2A subunit B isoform BRA; PP2A subunit B isoform BRB; PP2A subunit B isoform BRgamma; PP2A subunit B isoform delta; PP2A subunit B isoform gamma; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform PR55-gamma; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform R2-beta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform R2-gamma; PP2A, subunit B, B-alpha isoform; PP2A, subunit B, B-beta isoform; PP2A, subunit B, B-delta isoform; PP2A, subunit B, B-gamma isoform; PP2A, subunit B, B55-alpha isoform; PP2A, subunit B, B55-beta isoform; PP2A, subunit B, B55-delta isoform; PP2A, subunit B, B55-gamma isoform; PP2A, subunit B, BRA isoform; PP2A, subunit B, BRB isoform; PP2A, subunit B, BRgamma isoform; PP2A, subunit B, PR55-alpha isoform; PP2A, subunit B, PR55-beta isoform; PP2A, subunit B, PR55-delta isoform; PP2A, subunit B, PR55-gamma isoform; PP2A, subunit B, R2-alpha isoform; PP2A, subunit B, R2-beta isoform; PP2A, subunit B, R2-delta isoform; PP2A, subunit B, R2-gamma isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform; protein phosphatase 2 regulatory subunit B, alpha; protein phosphatase 2 regulatory subunit B, beta; protein phosphatase 2 regulatory subunit B, delta; protein phosphatase 2 regulatory subunit B, gamma; protein phosphatase 2, regulatory subunit B, alpha; protein phosphatase 2, regulatory subunit B, beta; protein phosphatase 2, regulatory subunit B, delta isoform; protein phosphatase 2A B regulatory subunit delta isoform; protein phosphatase 2A, regulatory subunit B, delta isoform; protein phosphatase 2A1 B gamma subunit; serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform; serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform; serine/threonine protein phosphatase 2A, neuronal isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; testicular tissue protein Li 156
Gene Aliases: 1300017E19Rik; 2410004D02Rik; 2900026H06Rik; 6330404L05Rik; 6330548O06Rik; B55-GAMMA; B55A; B55ALPHA; B55BETA; D7Ertd753e; E130009M08Rik; IMYPNO; IMYPNO1; KIAA1541; MDS026; mKIAA1541; PP2A-PR55B; PP2AB55BETA; PP2ABBETA; PP2APR55B; PP2APR55BETA; PPP2R2A; PPP2R2B; PPP2R2C; PPP2R2D; Pppr2b2; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52; PR52A; PR52B; PR55-BETA; PR55A; PR55BETA; PR55G; SCA12
UniProt ID: (Human) P63151, (Human) Q00005, (Human) Q9Y2T4, (Human) Q66LE6, (Mouse) Q6P1F6, (Rat) P36876, (Rat) P36877, (Mouse) Q6ZWR4, (Mouse) Q8BG02, (Rat) P97888, (Rat) P56932, (Mouse) Q925E7
Entrez Gene ID: (Human) 5520, (Human) 5521, (Human) 5522, (Human) 55844, (Mouse) 71978, (Rat) 117104, (Rat) 60660, (Mouse) 72930, (Mouse) 269643, (Rat) 117256, (Rat) 246255, (Mouse) 52432
G2/M transition of mitotic cell cycle
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
protein dephosphorylation
mitotic nuclear envelope reassembly
regulation of protein phosphatase type 2A activity
response to morphine
apoptotic process
mitotic nuclear division
exit from mitosis
cell division
signal transduction
regulation of catalytic activity
mitochondrial fission
protein targeting to mitochondrion
spermatid development
brain development
neuron differentiation
positive regulation of neuron apoptotic process
mitochondrial fragmentation involved in apoptotic process
dephosphorylation
cell cycle
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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