This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (96%), Rat (95%), Rabbit (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: Phosphotyrosyl phosphatase activator; PP2A phosphatase activator; PP2A subunit B' isoform PR53; PP2A, subunit B', PR53 isoform; PR53; protein phosphatase 2 regulatory subunit 4; protein phosphatase 2A; protein phosphatase 2A activator, regulatory subunit 4; protein phosphatase 2A regulatory subunit 4; protein phosphatase 2A, regulatory subunit B' (PR 53); PTPA; regulatory subunit B' (PR 53); Serine/threonine-protein phosphatase 2A activator; serine/threonine-protein phosphatase 2A regulatory subunit; Serine/threonine-protein phosphatase 2A regulatory subunit 4; Serine/threonine-protein phosphatase 2A regulatory subunit B'
Gene Aliases: PP2A; PPP2R4; PR53; PTPA
UniProt ID: (Human) Q15257
Entrez Gene ID: (Human) 5524