Immunogen sequence: GKLFDELTAS YKLEKQQEQQ KAQERQELWQ GLEELRLRRL QGTQGAKEAP LQRLTP
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B'/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: beta isoform of regulatory subunit B56, protein phosphatase 2A; PP2A B subunit isoform B'-beta; PP2A B subunit isoform B56-beta; PP2A B subunit isoform PR61-beta; PP2A B subunit isoform R5-beta; PP2A, B subunit, B' beta isoform; PP2A, B subunit, B56 beta isoform; PP2A, B subunit, PR61 beta isoform; PP2A, B subunit, R5 beta isoform; PPP2R5B; protein phosphatase 2 regulatory subunit B', beta; protein phosphatase 2, regulatory subunit B (B5; protein phosphatase 2, regulatory subunit B (B56), beta isoform; protein phosphatase 2, regulatory subunit B', beta isoform; serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, beta isoform; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
Gene Aliases: B'beta; B56B; BC026670; LOC100909468; PPP2R5B; PR61B; rCG_47223