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Proteintech
PPP3CC Polyclonal Antibody
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Product Details
19653-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPP3CC Fusion Protein Ag7619 (153-512 aa encoded by BC004864)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TDYFTFKQE CRIKYSEQVY DACMETFDCL PLAALLNQQF LCVHGGMSPE ITSLDDIRKL DRFTEPPAFG PVCDLLWSDP SEDYGNEKTL EHYTHNTVRG CSYFYSYPAV CEFLQNNNLL SIIRAHEAQD AGYRMYRKSQ ATGFPSLITI FSAPNYLDVY NNKAAVLKYE NNVMNIRQFN CSPHPYWLPN FMDVFTWSLP FVGEKVTEML VNVLNICSDD ELISDDEAEG STTVRKEIIR NKIRAIGKMA RVFSILRQES ESVLTLKGLT PTGTLPLGVL SGGKQTIETA TVEAVEAREA IRGFSLQHKI RSFEEARGLD RINERMPPRK DSIHAGGPMK SVTSAHSHAA HRSDQGKKAH S (153-512 aa encoded by BC004864)
Target Information
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Calcineurin A gamma; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform; CAM-PRP catalytic subunit; protein phosphatase 3, catalytic subunit, gamma isozyme; Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; unnamed protein product
Gene Aliases: CALNA3; Calnc; CNA3; PP2BA gamma; PP2Bgamma; PPP3CC
UniProt ID: (Human) P48454, (Mouse) P48455
Entrez Gene ID: (Human) 5533, (Mouse) 19057
protein dephosphorylation
calcineurin-NFAT signaling cascade
positive regulation of calcineurin-NFAT signaling cascade
calcineurin-mediated signaling
regulation of synaptic vesicle endocytosis
positive regulation of synaptic vesicle endocytosis
positive regulation of calcium ion import across plasma membrane
negative regulation of calcium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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