FIGURE: 1 / 6
Immunogen sequence: MAEISDLDR QIEQLRRCEL IKESEVKALC AKAREILVEE SNVQRVDSPV TVCGDIHGQF YDLKELFRVG GDVPETNYLF MGDFVDRGFY SVETFLLLLA LKVRYPDRIT LIRGNHESRQ ITQVYGFYDE CLRKYGSVTV WRYCTEIFDY LSLSAIIDGK IFCVHGGLSP SIQTLDQIRT IDRKQEVPHD GPMCDLLWSD PEDTTGWGVS PRGAGYLFGS DVVAQFNAAN DIDMICRAHQ LVMEGYKWHF NETVLTVWSA PNYCYRCGNV AAILELDEHL QKDFIIFEAA PQETRGIPSK KPVADYFL (1-307 aa encoded by BC001416)
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.
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Protein Aliases: P PPX; PP-X; pp4; PP4C; protein phosphatase 4 (formerly X), catalytic subunit; protein phosphatase 4, catalytic subunit; Protein phosphatase X; protein phosphatase X, catalytic subunit; Serine/threonine-protein phosphatase 4 catalytic subunit
Gene Aliases: 1110002D08Rik; AU016079; PP-X; PP4; PP4C; PPH3; PPP4; PPP4C; PPX
Molecular Function: protein phosphatase