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Invitrogen
PPP6C Recombinant Rabbit Monoclonal Antibody (6O2N8)
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FIGURE: 1 / 1
PPP6C Antibody (MA5-55531) in WB
Western Blot analysis of various lysates using PPP6C Recombinant Monoclonal Antibody (Product # MA5-55531) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
MA5-55531
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6O2N8
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 206-305 of human PPP6C.
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
Product Specific Information
Immunogen Sequence: AISPRGAGWL FGAKVTNEFV HINNLKLICR AHQLVHEGYK FMFDEKLVTV WSAPNYCYRC GNIASIMVFK DVNTREPKLF RAVPDSERVI PPRTTTPYFL
Target Information
Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5' to 3' exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5' and 3' overhang processing in nonhomologous DNA end joining.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANKRD33; FLJ34236; PP-V; PP6C; protein phosphatase 6, catalytic subunit; Protein phosphatase V; serine/threonine protein phosphatase catalytic subunit; Serine/threonine-protein phosphatase 6 catalytic subunit; UNQ5837
Gene Aliases: 2310003C10Rik; PP6; PP6C; PPP6; PPP6C; Ppv
UniProt ID: (Human) O00743, (Rat) Q64620, (Mouse) Q9CQR6
Entrez Gene ID: (Human) 5537, (Rat) 171121, (Mouse) 67857
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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