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Proteintech
PPPDE1/PNAS4 Polyclonal Antibody
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Product Details
20517-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPPDE1/PNAS4 Fusion Protein Ag14352 (1-194 aa encoded by BC004485)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody specifically recognized endogenous PPPDE1, which has been confirmed by siRNA test.
Immunogen sequence: MGANQLVVL NVYDMYWMNE YTSSIGIGVF HSGIEVYGRE FAYGGHPYPF SGIFEISPGN ASELGETFKF KEAVVLGSTD FLEDDIEKIV EELGKEYKGN AYHLMHKNCN HFSSALSEIL CGKEIPRWIN RLAYFSSCIP FLQSCLPKEW LTPAALQSSV SQELQDELEE AEDAAASASV ASTAAGSRPG RHTKL (1-194 aa encoded by BC004485)
Target Information
PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4. PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549. PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway. Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine. At least two isoforms of PNAS4 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DeSI-2; desumoylating isopeptidase 1; Desumoylating isopeptidase 2; Deubiquitinase DESI2; family with sequence similarity 152, member A; Palmitoyl protein thioesterase DESI2; PPPDE peptidase domain-containing protein 1; Protein FAM152A; S-depalmitoylase DESI2
Gene Aliases: C1orf121; CGI-146; DESI; DeSI-2; DESI1; DESI2; FAM152A; PNAS-4; PPPDE1
UniProt ID: (Human) Q9BSY9
Entrez Gene ID: (Human) 51029
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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