The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
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Protein Aliases: Acylation stimulating protein; acylation-stimulating protein cleavage product; Alkaline phosphatase Regan isozyme; Alkaline phosphatase, placental type; alkaline phosphomonoesterase; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3-beta-c; C3a anaphylatoxin; C3adesArg; C3bc; Complement C3; Complement C3 alpha chain; Complement C3 beta chain; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment; Complement C3dg fragment; Complement C3f fragment; Complement C3g fragment; complement component C3a; complement component C3b; epididymis secretory sperm binding protein Li 62p; glycerophosphatase; HSE-MSF; NR3C3; Nuclear receptor subfamily 3 group C member 3; Placental alkaline phosphatase 1; PLAP-1; PR; prepro-C3; Progesterone receptor
Gene Aliases: 9930019P03Rik; AHUS5; AI255234; ALP; ALPP; ARMD9; ASP; BB114106; C3; C3a; C3b; CPAMD1; ENSMUSG00000074510; HEL-S-62p; HSE-MSF; NR3C3; PALP; PGR; PLAP; PLAP-1; Plp; PR; PR-A; PR-B
Molecular Function: hydrolase phosphatase complement component cytokine defense/immunity protein enzyme modulator protease inhibitor serine protease inhibitor signaling molecule nuclear hormone receptor nucleic acid binding receptor transcription factor