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Invitrogen
PRAME Polyclonal Antibody
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FIGURE: 1 / 3
PRAME Antibody (PA5-13679) in IHC (P)
Immunohistochemistry analysis of PRAME in formalin fixed and paraffin embedded human testis tissue. Samples were incubated with PRAME polyclonal antibody (Product # PA5-13679) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-13679
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 476-502 amino acids from the C-terminal region of human MAPE
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cancer/testis antigen 130; Melanoma antigen preferentially expressed in tumors; OIP-4; Opa-interacting protein 4; Opa-interacting protein OIP4; Preferentially expressed antigen of melanoma
Gene Aliases: CT130; MAPE; OIP-4; OIP4; PRAME
UniProt ID: (Human) P78395
Entrez Gene ID: (Human) 23532
transcription, DNA-templated
apoptotic process
positive regulation of cell proliferation
cell differentiation
regulation of growth
negative regulation of apoptotic process
negative regulation of cell differentiation
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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