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Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAMEF6) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding.
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Protein Aliases: PRAME family member 6
Gene Aliases: PRAMEF6
UniProt ID: (Human) Q5VXH4
Entrez Gene ID: (Human) 440561
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