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Proteintech
PRAS40 Polyclonal Antibody
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Product Details
21097-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRAS40 Fusion Protein Ag15355 (1-256 aa encoded by BC051844)
Conjugate
Form
Liquid
Concentration
0.81 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASGRPEEL WEAVVGAAER FRARTGTELV LLTAAPPPPP RPGPCAYAAH GRGALAEAAR RCLHDIALAH RAATAARPPA PPPAPQPPSP TPSPPRPTLA REDNEEDEDE PTETETSGEQ LGISDNGGLF VMDEDATLQD LPPFCESDPE STDDGSLSEE TPAGPPTCSV PPASALPTQQ YAKSLPVSVP VWGFKEKRTE ARSSDEENGP PSSPDLDRIA ASMRALVLRE AEDTQVFGDL PRPRLNTSDF QKLKRKY (1-256 aa encoded by BC051844)
Target Information
The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can induce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 40 kDa proline-rich AKT substrate; AKT1 substrate 1 (proline rich); OTTHUMP00000196756; OTTHUMP00000196760; Proline-rich AKT1 substrate 1; unnamed protein product
Gene Aliases: AKT1S1; Lobe; PRAS40
UniProt ID: (Human) Q96B36
Entrez Gene ID: (Human) 84335
cytoplasmic translation
negative regulation of protein kinase activity
cellular response to nutrient levels
negative regulation of TOR signaling
TORC1 signaling
regulation of apoptotic process
regulation of neuron apoptotic process
negative regulation of cell size
negative regulation of translational initiation
positive regulation of translational initiation
neurotrophin TRK receptor signaling pathway
negative regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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