Immunogen sequence: KMQNMKKVIE AIRVELVQYW DQCFYSQEQR QAFAPFCAED YTESLLQLHD AEIVRLKNYY EVHKELFEGV QKWEETWRLF LEFERKASDP NRFTNRGGNL LKEEKQRAKL QKMLPKLEEE LKARIELWEQ EHSKAFMVNG QKFMEYV
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: anaphase spindle elongation 1 homolog; ASE1; PRC1; protein regulating cytokinesis 1; Protein regulator of cytokinesis 1
Gene Aliases: ASE1; D7Ertd348e; PRC1