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Invitrogen
PRDM14 Polyclonal Antibody
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FIGURE: 1 / 4
PRDM14 Antibody (PA1-114) in ICC/IF
Immunofluorescence analysis of PRDM14 (red, middle panel) in human embryonic stem cell H9 line grown on irradiated MEF-feeder layer. The cells were fixed with 4% paraformaldehyde at room temperature for 10 min and permeabilized with 0.25% Triton-X 100 for 5 min and blocked with the 10% BSA in PBS for 30 min at 37°C. Cells were stained with a PRDM14 polyclonal antibody (Product # PA1-114) at a dilution of 1:200 in 3% BSA/PBS blocking buffer overnight at 4°C, and then incubated with a RRX-conjugated donkey anti-rabbit IgG secondary antibody ... View More
Product Details
PA1-114
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human, full-length recombinant PRDM14
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.2-7.4, with 30% glycerol, 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PRDM14 encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PR domain 14; PR domain zinc finger protein 14; PR domain-containing 14; PR domain-containing protein 14; unnamed protein product; zinc finger protein
Gene Aliases: PFM11; PRDM14
UniProt ID: (Human) Q9GZV8
Entrez Gene ID: (Human) 63978
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
cell fate specification
inner cell mass cell fate commitment
regulation of transcription from RNA polymerase II promoter
germ cell development
embryo implantation
fibroblast growth factor receptor signaling pathway
fertilization
regulation of gene expression
stem cell population maintenance
germ-line stem cell population maintenance
methylation
regulation of gene expression, epigenetic
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of gene expression, epigenetic
homeostasis of number of cells within a tissue
positive regulation of sperm motility
positive regulation of stem cell population maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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