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Invitrogen
PRDM16 Polyclonal Antibody
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Product Details
PA5-20872
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Sheep
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide from near the carboxy terminus of human PRDM16.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA5-20872 can be used with blocking peptide PEP-0986.
Target Information
PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Histone-lysine N-methyltransferase PRDM16; line 27; MDS1/EVI1-like gene 1; PR domain 16; PR domain containing 16; PR domain zinc finger protein 16; PR domain-containing protein 16; PRDM16; PFM13; Transcription factor MEL1
Gene Aliases: 5730557K01Rik; CMD1LL; csp1; KIAA1675; KMT8F; LVNC8; MEL1; PFM13; PRDM16
UniProt ID: (Human) Q9HAZ2, (Mouse) A2A935
Entrez Gene ID: (Human) 63976, (Mouse) 70673
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription cofactor activity
transcription coactivator activity
protein binding
methyltransferase activity
zinc ion binding
transferase activity
sequence-specific DNA binding
metal ion binding
histone methyltransferase activity (H3-K9 specific)
DNA-binding transcription factor binding
histone H3 methyltransferase activity
histone H3K9me2 methyltransferase activity
histone H3K9 monomethyltransferase activity
nucleic acid binding
activating transcription factor binding
SMAD binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
cell differentiation
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of granulocyte differentiation
methylation
regulation of cellular respiration
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
brown fat cell differentiation
heterochromatin organization
positive regulation of cold-induced thermogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
stem cell population maintenance
neurogenesis
somatic stem cell population maintenance
tongue development
white fat cell differentiation
palate development
positive regulation of brown fat cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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