Immunogen sequence: MLGMYVPDRF SLKSSRVQDG MGLYTARRVR KGEKFGPFAG EKRMPEDLDE NMDYRLMWEV RGSKGEVLYI LDATNPRHSN WLRFVHEAPS QEQKNLAAIQ; Positive Samples: Mouse kidney, Mouse heart, Mouse lung, Mouse ovary, Rat kidney, Rat liver; Cellular Location: Nucleus
PRDM5, a novel member of PR domain protein family, contains a PR-domain at the -NH2 terminus followed by 16 zinc finger motifs. It is found to have a role in cell differentiation and tumorigenesis. Reports suggest PRDM5 causes G2/M arrest and apoptosis upon infection of tumor cells and has been found to be silenced in breast, ovarian and lung cancers, suggesting a potential clinical significance.
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Protein Aliases: PR domain containing 5; PR domain zinc finger protein 5; PR domain-containing protein 5
Gene Aliases: 4432417F03Rik; 6530401I24Rik; AI197291; BCS2; E130112L17Rik; PFM2; PRDM5
Molecular Function: C2H2 zinc finger transcription factor