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Invitrogen
PRDX1 Polyclonal Antibody
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FIGURE: 1 / 7
PRDX1 Antibody (PA3-750) in ICC/IF
Immunofluorescence analysis of Peroxiredoxin 1 was performed using 70% confluent log phase T-47D cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with PRDX1 Rabbit Polyclonal (Product # PA3-750) at 1:250 dilution in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Pro... View More
Product Details
PA3-750
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues L(103) V S D P K R T I A Q D(114) of human Peroxiredoxin 1.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA3-750 detects Peroxiredoxin 1 protein in human, rat and mouse samples. This antibody is specific for Prx 1 and shows no cross-reactivity with other Prx isoforms.
PA3-750 has successfully been used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects an ~26 kDa protein representing Prx 1 in human PC3 cell lysate.
The PA3-750 immunizing peptide corresponds to amino acid residues 103-114 from human Prx 1.
Target Information
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ACR1; Alu co-repressor 1; AOEB166; B166; HBP23; Heme-binding 23 kDa protein; macrophage 23 Kd stress protein; Macrophage 23 kDa stress protein; macrophage 23kDa stress protein; macrophase stress protein 22kDa; macrophase stress protein 23 kd; Natural killer cell-enhancing factor A; natural killer-enhancing factor A; NKEF-A; OSF-3; osteoblast specific factor 3; Osteoblast-specific factor 3; PAG; Peroxiredoxin-1; proliferation-associated gene A; Proliferation-associated gene protein; Prx; Prx 1; thioredoxin dependent peroxide reductase 2; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; Thioredoxin-dependent peroxiredoxin 1; Trx dependent peroxide reductase 2
Gene Aliases: Hbp23; MSP23; NKEF-A; NKEFA; OSF-3; OSF3; PAG; PAGA; PAGB; PRDX1; PrdxI; PRX1; PRXI; TDPX2; TDX2; TPxA
UniProt ID: (Human) Q06830, (Mouse) P35700, (Rat) Q63716
Entrez Gene ID: (Human) 5052, (Mouse) 18477, (Rat) 117254
response to reactive oxygen species
skeletal system development
retina homeostasis
cell proliferation
removal of superoxide radicals
regulation of stress-activated MAPK cascade
erythrocyte homeostasis
natural killer cell mediated cytotoxicity
regulation of NF-kappaB import into nucleus
hydrogen peroxide catabolic process
cell redox homeostasis
oxidation-reduction process
cell-cell adhesion
response to oxidative stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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