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Invitrogen
PRDX2 Polyclonal Antibody
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FIGURE: 1 / 1
PRDX2 Antibody (PA5-95989) in WB
Western blot analysis of PRDX2 in extracts from normal (control) and Peroxiredoxin 2 (Peroxiredoxin 2 (PRDX2)) knockout (KO) 293T cells. Samples were incubated with PRDX2 Polyclonal antibody (Product # PA5-95989) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-95989
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
2.19 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN RAEDFRKLGC EVLGVSVDSQ FTHLAWYEQG PKREVAAKLT PSGPSSVASW PLLNLWNLRF PIVKIMETLP PKSLRMMTVI SI; Positive Samples: SW480, 22Rv1, HepG2, K-562, BT-474, Mouse brain, Mouse kidney; Cellular Location: Cytoplasm
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calpromotin; epididymis secretory sperm binding protein Li 2a; HGNC:9353; MGC4104; Natural killer cell-enhancing factor B; NKEF-B; Peroxiredoxin-2; protector protein; PRP; Prx II-1; thiol specific antioxidant protein; thiol-specific antioxidant 1; Thiol-specific antioxidant protein; thioredoxin dependent peroxide reductase 1; Thioredoxin peroxidase 1; thioredoxin reductase; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2; torin; Trx dependent peroxide reductase 1; TSA
Gene Aliases: AL022839; Band-8; HEL-S-2a; NKEF-B; NKEFB; PRDX2; PRP; PRX2; PRXII; PTX1; TDPX1; TDX1; Torin; TPx; TPx-B; TPX1; TR; TSA
UniProt ID: (Human) P32119, (Mouse) Q61171, (Rat) P35704
Entrez Gene ID: (Human) 7001, (Mouse) 21672, (Rat) 29338
response to reactive oxygen species
response to oxidative stress
removal of superoxide radicals
cellular response to oxidative stress
hydrogen peroxide catabolic process
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cell redox homeostasis
oxidation-reduction process
activation of MAPK activity
respiratory burst involved in inflammatory response
regulation of hydrogen peroxide metabolic process
positive regulation of blood coagulation
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
response to lipopolysaccharide
T cell proliferation
hydrogen peroxide metabolic process
negative regulation of T cell differentiation
thymus development
homeostasis of number of cells
negative regulation of reactive oxygen species metabolic process
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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