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Invitrogen
PRDX3 Polyclonal Antibody
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Product Details
PA5-116556
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 63-256 of human Peroxiredoxin 3 (Peroxiredoxin 3 (PRDX3)) (NP_0067841)
Conjugate
Form
Liquid
Concentration
1.01 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: U-87MG, HeLa, LO2, A-549, Mouse kidney
Immunogen sequence: PAVTQHAPYF KGTAVVNGEF KDLSLDDFKG KYLVLFFYPL DFTFVCPTEI VAFSDKANEF HDVNCEVVAV SVDSHFSHLA WINTPRKNGG LGHMNIALLS DLTKQISRDY GVLLEGSGLA LRGLFIIDPN GVIKHLSVND LPVGRSVEET LRLVKAFQYV ETHGEVCPAN WTPDSPTIKP SPAASKEYFQ KVNQ
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anti-oxidant protein 1; antioxidant protein; Antioxidant protein 1; AOP-1; epididymis secretory sperm binding protein; HBC189; mitochondrial thioredoxin dependent peroxide reductase; mitochondrial Trx dependent peroxide reductase; Perioredoxin-3; Peroxiredoxin III; Peroxiredoxin-3; PRDX3; Protein MER5; Protein MER5 homolog; Prx; Prx 3; PRX III; PRX-3; Prx-III; Thioredoxin-dependent peroxide reductase, mitochondrial; Thioredoxin-dependent peroxiredoxin 3; unnamed protein product
Gene Aliases: AOP-1; AOP1; AW822249; D0Tohi1; Ef2l; HBC189; MER5; PPPCD; PRDX3; PRO1748; prx-III; Prx3; SCAR32; SP-22; SP22; TDXM
UniProt ID: (Human) P30048, (Mouse) P20108, (Rat) Q9Z0V6
Entrez Gene ID: (Human) 10935, (Mouse) 11757, (Rat) 64371
peroxidase activity
protein binding
thioredoxin peroxidase activity
antioxidant activity
oxidoreductase activity
protein kinase binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
peroxiredoxin activity
NADH-dependent peroxiredoxin activity
thioredoxin-dependent peroxiredoxin activity
protein C-terminus binding
kinase binding
molecular_function
peroxidase
maternal placenta development
response to oxidative stress
mitochondrion organization
positive regulation of cell proliferation
myeloid cell differentiation
response to lipopolysaccharide
negative regulation of kinase activity
cellular response to oxidative stress
cellular response to reactive oxygen species
response to hydrogen peroxide
hydrogen peroxide catabolic process
negative regulation of apoptotic process
cell redox homeostasis
positive regulation of NF-kappaB transcription factor activity
regulation of mitochondrial membrane potential
cellular oxidant detoxification
apoptotic process
peptidyl-cysteine oxidation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of neuron apoptotic process
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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