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Product Details
PA5-144908
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 165-200. Recombinant protein control fragment (Product #RP-109866).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3092344
Product Specific Information
Immunogen sequence: TKQISRDYGV LLEGSGLALR GLFIIDPNGV IKHLSV
Antigen sequence identity: Mouse 89%; Rat 92%
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antioxidant protein 1; AOP-1; HBC189; Peroxiredoxin III; Peroxiredoxin-3; Protein MER5 homolog; Prx; Prx 3; Prx-III; Thioredoxin-dependent peroxide reductase, mitochondrial; Thioredoxin-dependent peroxiredoxin 3
Gene Aliases: AOP-1; AOP1; HBC189; MER5; PRDX3; PRO1748; prx-III; SP-22
UniProt ID: (Human) P30048
Entrez Gene ID: (Human) 10935
response to reactive oxygen species
maternal placenta development
apoptotic process
response to oxidative stress
mitochondrion organization
positive regulation of cell proliferation
peptidyl-cysteine oxidation
myeloid cell differentiation
response to lipopolysaccharide
negative regulation of kinase activity
cellular response to oxidative stress
cellular response to reactive oxygen species
response to hydrogen peroxide
hydrogen peroxide catabolic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cell redox homeostasis
positive regulation of NF-kappaB transcription factor activity
regulation of mitochondrial membrane potential
cellular oxidant detoxification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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