Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Rhesus Monkey (100%), Bovine (100%).
Positive Control: 293T, A431, HeLa, HepG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Antioxidant enzyme AOE372; antioxidant enzyme AOE372 antibody; AOE37-2; AOE37-2 antibody; epididymis secretory sperm binding protein Li 97n; peroxiredoxin 4 antibody; Peroxiredoxin IV; peroxiredoxin IV antibody; Peroxiredoxin-4; peroxiredoxin-4 antibody; PRDX4 antibody; Prx IV; PRX-4 antibody; Prx-IV; prx-IV antibody; thioredoxin peroxidase (antioxidant enzyme); thioredoxin peroxidase (antioxidant enzyme) antibody; Thioredoxin peroxidase AO372; thioredoxin peroxidase AO372 antibody; Thioredoxin-dependent peroxide reductase A0372; thioredoxin-dependent peroxide reductase A0372 antibody
Gene Aliases: AOE37-2; AOE372; HEL-S-97n; PRDX4; PRX-4; Prx-iv; Prx4; TRANK