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Invitrogen
PRDX6 Polyclonal Antibody
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Product Details
PA5-96040
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human Peroxiredoxin 6 (NP_0048961)
Conjugate
Form
Liquid
Concentration
1.06 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE FAKRNVKLIA LSIDSVEDHL AWSKDINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGRNFDEI LRVVISLQLT AEKRVATPVD WKDGDSVMVL PTIPEEEAKK LFPKGVFTKE LPSGKKYLRY TPQP; Positive Samples: HeLa, PC-3, K-562, BT-474, Mouse liver, Mouse heart; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Lysosome
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-Cys peroxiredoxin; 1-Cys PRX; 24 kDa protein; Acidic calcium-independent phospholipase A2; aiPLA2; Antioxidant protein 2; epididymis secretory sperm binding protein Li 128m; Glutathione-dependent peroxiredoxin; KIAA0106; Liver 2D page spot 40; LPC acyltransferase 5; lyso-PC acyltransferase 5; Lysophosphatidylcholine acyltransferase 5; MGC46173; MSP23; NKEFA; Non-selenium glutathione peroxidase; NSGPx; PAG; PAGA; PAGB; Peroxiredoxin-6; Prx6; Red blood cells page spot 12; Thiol-specific antioxidant protein; unnamed protein product
Gene Aliases: 1-Cys; 1-Cys Prx; 1-cysPrx; 9430088D19Rik; AA690119; Aipla2; AOP2; Brp-12; CP-3; GPx; HEL-S-128m; KIAA0106; LPCAT-5; Ltw-4; Ltw4; Lvtw-4; NSGPx; ORF06; p29; Prdx5; PRDX6; PRX; Tsa
UniProt ID: (Human) P30041, (Mouse) O08709, (Rat) O35244
Entrez Gene ID: (Human) 9588, (Mouse) 11758, (Rat) 94167
catalytic activity
peroxidase activity
glutathione peroxidase activity
phospholipase A2 activity
protein binding
antioxidant activity
oxidoreductase activity
transferase activity
hydrolase activity
ubiquitin protein ligase binding
identical protein binding
cadherin binding
1-acylglycerophosphocholine O-acyltransferase activity
calcium-independent phospholipase A2 activity
peroxiredoxin activity
peroxidase
lipid metabolic process
response to oxidative stress
lipid catabolic process
hydrogen peroxide catabolic process
cell redox homeostasis
glycerophospholipid catabolic process
positive regulation of mRNA splicing, via spliceosome
cellular oxidant detoxification
response to reactive oxygen species
phospholipid catabolic process
bleb assembly
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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