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Invitrogen
PREX1 Polyclonal Antibody
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FIGURE: 1 / 2
PREX1 Antibody (PA5-34962) in WB
PREX1 Polyclonal Antibody detects PREX1 protein by Western blot analysis. A. 1 µg 293T whole cell lysate/extract. B. 1 µg whole cell lysate/extract of PREX1-transfected 293T cells.5 % SDS-PAGE. PREX1 Polyclonal Antibody (Product # PA5-34962) dilution: 1:10,000.
Product Details
PA5-34962
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PREX1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: THP-1, PREX1-transfected 293T cells.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000031228; P-Rex1; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; PIP3 dependent Rac exchange factor 1; PREX 1; PREX-1; ptdIns(3,4,5)-dependent Rac exchanger 1
Gene Aliases: KIAA1415; P-REX1; PREX1
UniProt ID: (Human) Q8TCU6
Entrez Gene ID: (Human) 57580
superoxide metabolic process
G-protein coupled receptor signaling pathway
actin filament polymerization
T cell differentiation
positive regulation of cell migration
neutrophil chemotaxis
regulation of actin filament polymerization
negative regulation of TOR signaling
intracellular signal transduction
neutrophil activation
leukocyte activation
positive regulation of cell adhesion
regulation of dendrite development
regulation of small GTPase mediated signal transduction
reactive oxygen species metabolic process
positive regulation of substrate adhesion-dependent cell spreading
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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