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Proteintech
PRKAR2A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
10142-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRKAR2A Fusion Protein Ag0203 (74-382 aa encoded by BC002763)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody got two bands about 45 kDa and 50-55 kDa in western blotting, and the 50-55 kDa may be caused by phosphorylation.
Immunogen sequence: AKGDSESEE DEDLEVPVPS RFNRRVSVCA ETYNPDEEEE DTDPRVIHPK TDEQRCRLQE ACKDILLFKN LDQEQLSQVL DAMFERIVKA DEHVIDQGDD GDNFYVIERG TYDILVTKDN QTRSVGQYDN RGSFGELALM YNTPRAATIV ATSEGSLWGL DRVTFRRIIV KNNAKKRKMF ESFIESVPLL KSLEVSERMK IVDVIGEKIY KDGERIITQT KSNKDGGNQE VEIARCHKGQ YFGELALVTN KPRAASAYAV GDVKCLVMDV QAFERLLGPC MDIMKRNISH YEEQLVKMFG SSVDLGNLGQ (74-382 aa encoded by BC002763)
Target Information
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of AMPK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cAMP-dependent protein kinase regulatory subunit RII alpha; MGC3606; protein kinase A, RII-alpha subunit; protein kinase cAMP-dependent type 2 regulatory subunit alpha; protein kinase type II regulatory subunit (, EC 2.7.1.37); protein kinase, cAMP dependent regulatory, type II alpha; protein kinase, cAMP-dependent, regulatory subunit type II alpha; protein kinase, cAMP-dependent, regulatory, type 2, alpha; unnamed protein product
Gene Aliases: 1110061A24Rik; PKR2; PRKAR2; RII(alpha)
UniProt ID: (Human) P13861, (Rat) P12368
Entrez Gene ID: (Human) 5576, (Rat) 29699, (Mouse) 19087
cAMP-dependent protein kinase inhibitor activity
protein binding
cAMP-dependent protein kinase regulator activity
protein domain specific binding
cAMP binding
ubiquitin protein ligase binding
protein kinase A catalytic subunit binding
beta-2 adrenergic receptor binding
small molecule binding
identical protein binding
macromolecular complex binding
adenylate cyclase-activating G-protein coupled receptor signaling pathway
regulation of protein kinase activity
modulation of synaptic transmission
negative regulation of cAMP/PKA signal transduction
regulation of meiotic cell cycle process involved in oocyte maturation
positive regulation of meiotic cell cycle process involved in oocyte maturation
negative regulation of cAMP-dependent protein kinase activity
negative regulation of inflammatory response to antigenic stimulus
renal water homeostasis
chemical synaptic transmission
activation of protein kinase A activity
intracellular signal transduction
cellular response to glucagon stimulus
vascular endothelial cell response to laminar fluid shear stress
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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