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This antibody got two bands about 45 kDa and 50-55 kDa in western blotting, and the 50-55 kDa may be caused by phosphorylation.
Immunogen sequence: AKGDSESEE DEDLEVPVPS RFNRRVSVCA ETYNPDEEEE DTDPRVIHPK TDEQRCRLQE ACKDILLFKN LDQEQLSQVL DAMFERIVKA DEHVIDQGDD GDNFYVIERG TYDILVTKDN QTRSVGQYDN RGSFGELALM YNTPRAATIV ATSEGSLWGL DRVTFRRIIV KNNAKKRKMF ESFIESVPLL KSLEVSERMK IVDVIGEKIY KDGERIITQT KSNKDGGNQE VEIARCHKGQ YFGELALVTN KPRAASAYAV GDVKCLVMDV QAFERLLGPC MDIMKRNISH YEEQLVKMFG SSVDLGNLGQ (74-382 aa encoded by BC002763)
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of AMPK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cAMP-dependent protein kinase regulatory subunit RII alpha; cAMP-dependent protein kinase type II-alpha regulatory subunit; MGC3606; protein kinase A, RII-alpha subunit; protein kinase cAMP-dependent regulatory type II alpha; protein kinase, cAMP-dependent, regulatory subunit type II alpha; protein kinase, cAMP-dependent, regulatory, type 2, alpha
Gene Aliases: 1110061A24Rik; AI317181; AI836829; PKR2; PRKAR2; PRKAR2A; RII(alpha)
UniProt ID: (Human) P13861, (Rat) P12368
Entrez Gene ID: (Human) 5576, (Mouse) 19087, (Rat) 29699
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