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Invitrogen
PRKAR2B Polyclonal Antibody
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FIGURE: 1 / 8
PRKAR2B Antibody (PA5-13799) in WB
Western blot analysis of PRKAR2B in 293 cell lysates. Samples were incubated with PRKAR2B polyclonal antibody (Product # PA5-13799). Lysates: 2 µg/lane. 293 cell lysates either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PRKAR2B gene.
Product Details
PA5-13799
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 32-62 amino acids from the N-terminal region of human PKA 2 beta (PRKAR2B)
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cAMP-dependent protein kinase type II-beta regulatory chain; cAMP-dependent protein kinase type II-beta regulatory subunit; H_RG363E19.2; protein kinase, cAMP-dependent, regulatory subunit type II beta; protein kinase, cAMP-dependent, regulatory, type II, beta; unnamed protein product; WUGSC:H_RG363E19.2
Gene Aliases: AI451071; AW061005; Pkarb2; PKARIIbeta; PRKAR2; PRKAR2B; RII(beta); RII-BETA
UniProt ID: (Human) P31323, (Mouse) P31324
Entrez Gene ID: (Human) 5577, (Mouse) 19088
nucleotide binding
cAMP-dependent protein kinase inhibitor activity
protein binding
cAMP-dependent protein kinase regulator activity
protein kinase binding
protein domain specific binding
cAMP binding
ubiquitin protein ligase binding
protein kinase A catalytic subunit binding
protein-binding activity modulator
kinase modulator
fatty acid metabolic process
adenylate cyclase-activating G-protein coupled receptor signaling pathway
learning
intracellular signal transduction
modulation of synaptic transmission
response to antipsychotic drug
negative regulation of cAMP/PKA signal transduction
regulation of protein phosphorylation
regulation of protein kinase activity
negative regulation of cAMP-dependent protein kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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