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Invitrogen
PRKAR2B Polyclonal Antibody
Product Details
PA5-28266
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 177 and 391 of Human PKA 2 beta
Conjugate
Form
Liquid
Concentration
0.67 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545742
Product Specific Information
Recommended positive controls: HeLa, HepG2, mouse brain, rat brain.^M
^M
Predicted reactivity: Mouse (97%), Rat (96%), Xenopus laevis (84%), Bovine (99%).^M
^M
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cAMP-dependent protein kinase type II-beta regulatory chain; cAMP-dependent protein kinase type II-beta regulatory subunit; H_RG363E19.2; protein kinase, cAMP-dependent, regulatory subunit type II beta; protein kinase, cAMP-dependent, regulatory, type II, beta; Type II beta regulatory subunit of cAMP-dependent protein kinase; WUGSC:H_RG363E19.2
Gene Aliases: AI451071; AW061005; Pkarb2; PKARIIbeta; PRKAR2; PRKAR2B; RATDNA; RII(beta); RII-BETA
UniProt ID: (Human) P31323, (Mouse) P31324, (Rat) P12369
Entrez Gene ID: (Human) 5577, (Mouse) 19088, (Rat) 24679
cAMP-dependent protein kinase inhibitor activity
protein binding
cAMP-dependent protein kinase regulator activity
protein domain specific binding
cAMP binding
ubiquitin protein ligase binding
protein kinase A catalytic subunit binding
nucleotide binding
protein kinase binding
protein-binding activity modulator
kinase modulator
G2/M transition of mitotic cell cycle
renal water homeostasis
fatty acid metabolic process
blood coagulation
learning
activation of protein kinase A activity
intracellular signal transduction
cellular response to glucagon stimulus
response to antipsychotic drug
response to clozapine
negative regulation of cAMP-dependent protein kinase activity
regulation of protein phosphorylation
regulation of protein kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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